In this article, the effects of educational and literary services of Sir Syed Ahmad Khan have been highlighted on Sindhi literature and Sindhi people. Just as Sir Syed and his colleagues left a great impact in the field of education and literature in Sindh, Hasan Ali Afandi and his colleagues Molana Allah Bakhsh Abuhjo and Rayees Shams-ud-Din Bulbul also rendered educational and literary services for the development of Sindhi people and Sindhi literature. This comparative study also mentions the services of some other Sindhi natives in the field of educational and literary development.